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Human islets from Oxford were isolated within the Diabetes Research and Wellness Foundation (DRWF) Human Islet Isolation Facility

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in the presence of this alternate substrate, the reaction yields malonic acid semialdehyde, formaldehyde (akin to the action of histone demethylases), dimethylamine, and (1-methylimidazolidin-4-yl)acetic acid, "an unexpected product with an additional carbon-carbon bond resulting from N-demethylation coupled to oxidative rearrangement, likely via an unusual radical mechanism." [13] [12] The unusual mechanism is thought likely to involve a Steven's type rearrangement